The brightest and most creative minds in the hedge fund industry will be under one roof Wednesday when Delivering Alpha convenes at the Pierre Hotel in New York City. Now in its third year, the conference has established itself as a preeminent event at which top managers and investors talk shop.

For the third straight year, Delivering Alpha starts with a bang — an interview with the current U.S. Treasury Secretary (this time it's Jack Lew). At last year's meeting then–Treasury Secretary Timothy Geithner kicked off the day with a wide-ranging interview by CNBC's Larry Kudlow, host of the nightly Kudlow Report. Private equity giant Henry Kravis delivered the lunch keynote as attendees tried to listen between bites of filet. And, of course, U.S. Attorney for the Southern District of New York Preet Bharara — the sheriff of Wall Street — was extremely candid, and funny, in his sit-down with Mad Money's Jim Cramer.

This year, it only gets better.

Bharara will return on Wednesday, and with apologies to all who will be in attendance, he will probably have enough subpoenas this time around. One of the U.S.'s more recognizable lawyers has become a household name in the industry as insider-trading cases engulf the news.

This year's panelists represent some of the smartest names in the investment game. Joining holdovers Leon Cooperman of Omega Advisors and Jim Chanos of Kynikos Associates on the must-see My New Best Idea panel are Delivering Alpha newcomers Chris Hohn of the Children's Investment Fund Management (UK) and Mark Kingdon of Kingdon Capital Management. Hohn's former boss Richard Perry will be back on the Global Stage panel, along with J.P. Morgan Asset Management CEO Mary Callahan Erdoes and Harvard Management Co. chief Jane Mendillo to discuss the world at large and the investment opportunities in it. They will be joined by Bridgewater Associates co-president David McCormick.

Another new name to grace Delivering Alpha this year will be Farallon Capital Management managing partner Andrew J.M. Spokes, who took over from founder Thomas Steyer after he retired at the end of 2012. The new head of the approximately $19 billion San Francisco–based firm shares a panel with Morgan Stanley Investment Management president Gregory Fleming, CQS founder and CEO Michael Hintze and Canyon Capital co-founder Joshua Friedman to talk about one of the most intriguing issues that investors face today — the great rotation from bonds to stocks.